ΔE 21.2, loose: different enough that you should pick on purpose. Scrofulous Brown is noticeably lighter, much more saturated than Orange Brown.
Not as a straight swap; see the closer alternatives below. Loose match (ΔE 21). Scrofulous Brown is noticeably lighter, much more saturated than Orange Brown.
The same difference applies the other way round: Orange Brown is noticeably darker, much more muted.
ΔE is the colour difference between our two swatch estimates: under about 6 is close, over about 15 is loose. Real paints also differ in finish, coverage and how they thin, so test before you commit.
See Orange Brown on the colour wheel See Scrofulous Brown on the colour wheel
All matches: Orange Brown equivalents · Scrofulous Brown equivalents