ΔE 25.6, loose: different enough that you should pick on purpose. Ink Red is much more saturated, cooler than Siena.
Not as a straight swap; see the closer alternatives below. Loose match (ΔE 26). Ink Red is much more saturated, cooler than Siena.
The same difference applies the other way round: Siena is much more muted, warmer.
ΔE is the colour difference between our two swatch estimates: under about 6 is close, over about 15 is loose. Real paints also differ in finish, coverage and how they thin, so test before you commit.
See Siena on the colour wheel See Ink Red on the colour wheel
All matches: Siena equivalents · Ink Red equivalents