ΔE 19.5, loose: different enough that you should pick on purpose. Ink Skin is noticeably darker, more muted, cooler than Sepia.
Not as a straight swap; see the closer alternatives below. Loose match (ΔE 20). Ink Skin is noticeably darker, more muted, cooler than Sepia.
The same difference applies the other way round: Sepia is noticeably lighter, more saturated, warmer.
ΔE is the colour difference between our two swatch estimates: under about 6 is close, over about 15 is loose. Real paints also differ in finish, coverage and how they thin, so test before you commit.
See Sepia on the colour wheel See Ink Skin on the colour wheel
All matches: Sepia equivalents · Ink Skin equivalents