Khador Red Highlight vs Hot Orange

How close are they?

ΔE 27.4, loose: different enough that you should pick on purpose. Hot Orange is noticeably darker, more saturated, cooler than Khador Red Highlight.

Can I use Hot Orange instead of Khador Red Highlight?

Not as a straight swap; see the closer alternatives below. Loose match (ΔE 27). Hot Orange is noticeably darker, more saturated, cooler than Khador Red Highlight.

Can I use Khador Red Highlight instead of Hot Orange?

The same difference applies the other way round: Khador Red Highlight is noticeably lighter, more muted, warmer.

ΔE is the colour difference between our two swatch estimates: under about 6 is close, over about 15 is loose. Real paints also differ in finish, coverage and how they thin, so test before you commit.