Gladeshard vs Cygnus Yellow

How close are they?

ΔE 37.0, loose: different enough that you should pick on purpose. Cygnus Yellow is noticeably lighter, more saturated, warmer than Gladeshard.

Can I use Cygnus Yellow instead of Gladeshard?

Not as a straight swap; see the closer alternatives below. Loose match (ΔE 37). Cygnus Yellow is noticeably lighter, more saturated, warmer than Gladeshard.

Can I use Gladeshard instead of Cygnus Yellow?

The same difference applies the other way round: Gladeshard is noticeably darker, more muted, cooler.

ΔE is the colour difference between our two swatch estimates: under about 6 is close, over about 15 is loose. Real paints also differ in finish, coverage and how they thin, so test before you commit.