ΔE 15.9, loose: different enough that you should pick on purpose. Desert Skin is a little lighter, much more muted than Leather Brown.
Not as a straight swap; see the closer alternatives below. Loose match (ΔE 16). Desert Skin is a little lighter, much more muted than Leather Brown.
The same difference applies the other way round: Leather Brown is a little darker, much more saturated.
ΔE is the colour difference between our two swatch estimates: under about 6 is close, over about 15 is loose. Real paints also differ in finish, coverage and how they thin, so test before you commit.
See Leather Brown on the colour wheel See Desert Skin on the colour wheel
All matches: Leather Brown equivalents · Desert Skin equivalents